CareerChem
Green Chemistry Homepage
http://www.crcpress.com/product/isbn/9781420093285
(The Algebra of Organic Synthesis)
http://www.crcpress.com/product/isbn/9781439840764
(Green Organic Chemistry in Lecture and Laboratory)
http://www.crcpress.com/product/isbn/9780367002251
Synthesis Green Metrics: Problems, Exercises and Solutions
http://www.crcpress.com/product/isbn/9781138388949
Reaction Green Metrics: Problems, Exercises and Solutions
Books and Book Chapters:
J. Andraos, Reaction Green Metrics – Problems, Exercises, and Solutions, CRC Press-Taylor & Francis: Boca Raton, 2019.
J. Andraos, Synthesis Green Metrics – Problems, Exercises, and Solutions, CRC Press-Taylor & Francis: Boca Raton, 2019.
J. Andraos, Application of Step, Cumulative, and Global E-factor and PMI Metrics to Gauge Synthesis Efficiency: L-DOPA and Apixaban Pharmaceutical Examples in Green Synthetic
Processes and Procedures, (R. Ballini, ed.), Royal Chemical Society: United Kingdom, 2019, Chapter 3, pp. 39-52.
J. Andraos and A. Hent, Key Metrics to Inform Chemical Synthesis Route Design in Handbook of Green Chemistry, Volume 11, (D.J.C. Constable, C. Jiménez-González, eds.), Wiley-VCH,
2018, Chapter 3, pp. 49-94.
J. Andraos, Application of Green Metrics Analysis to the Synthesis of Dicyclohexylcarbodiimide (DCC) – comparison of chlorine versus non-chlorine based routes in Chemistry Beyond Chlorine, (P. Tundo, L.N. He, E. Lokteva, C. Mota, eds.), Springer-Verlag, 2016, Chapter 22, pp. 587 – 604.
J. Andraos and A.P. Dicks, The State of Green Chemistry Instruction at Canadian Universities in Worldwide Trends in Green Chemistry Education, (V. Zuin, L. Mammino, eds.), Royal Society of Chemistry, 2015, Chapter 11, pp. 179 – 212.
P. Tundo and J. Andraos (eds.), Green Syntheses Volume 1, CRC Press-Taylor & Francis: Boca Raton, 2014.
J. Andraos*, Application of Green Metrics to Scalable Industrial Synthesis Plans: An Update on Syntheses of Oseltamivir Phosphate (Tamiflu) in Scalable Green Chemistry: Case Studies from the Pharmaceutical Industry, (S.G. Koenig, ed.), Pan Stanford Publishing: 2013, Chapter 4, pp. 75 – 104.
J. Andraos*, Green Chemistry Metrics: Material Efficiency and Strategic Synthesis Design in Innovations in Green Chemistry and Green Engineering, (P.T. Anastas, J.B. Zimmerman, eds.), Springer: New York, 2013, Chapter 4, pp. 81 – 113.
J. Andraos*, Designing a Green Organic Chemistry Lecture Course in Green Organic Chemistry in Lecture and Laboratory, (A.P. Dicks, ed.), Taylor & Francis: Boca Raton, 2012, Chapter 2, pp. 29 - 68.
J. Andraos*, Parameterization and Tracking of Optimization of Synthesis Strategy Using Computer Spreadsheet Algorithms in Handbook of Green Chemistry, Volume 7 – Green Processes (P.T. Anastas, C.J. Li, eds.), Wiley-VCH: Weinheim, 2012, Chapter 13.
J. Andraos*, Green Chemistry Metrics: Material Efficiency and Strategic Synthesis Design in Encyclopedia of Sustainability Science and Technology, (P.T. Anastas, J. Zimmerman, eds.), Springer-Verlag: New York, 2011.
J. Andraos*, Application of Green Metrics Analysis to Chemical Reactions and Synthesis Plans, in Green Chemistry Metrics in Green Chemistry Metrics, (Alexei Lapkin, David C. Constable, eds.), Blackwell Scientific: Oxford, 2008. Chapter 4, pp. 69 - 199.
J. Andraos*, Atom Economy, Reaction Mass Efficiency, and E-factor Green Metrics for Gauging Material Efficiencies of Reactions and Synthesis Plans: Paradigms and Examples in The Oxford Handbook of Green Chemistry, (W.M. Nelson, ed.), Oxford University Press: New York. [Note: This book has been withdrawn from Oxford University Press]
Publications:
J. Andraos*, A Proposed Sustainability Index for Synthesis Plans Based on Input Provenance and Output Fate: Application to Academic and Industrial Synthesis Plans for Vanillin as a Case Study, Beilstein J. Org. Chem. 2020, 16, 2346-2362. doi:10.3762/bjoc.16.196 (open access article)
J. Andraos*, Aiming for a Standardized Protocol for Preparing a Process Green Synthesis Report and for Ranking Multiple Synthesis Plans to a Common Target Product, Green
Processing & Synthesis 2019, 8, 787-801. doi:10.1515/gps-2019-0048 (open access article)
J. Andraos*, Evaluation of Industrial Routes to Vinyl Chloride According to Material and Energy Efficiency Metrics Analysis, ChemRxiv 2019, doi: 10.26434/chemrxiv.7688183
J. Andraos*, Relationships Between Step and Cumulative PMI and E-factors: Implications on Estimating Material Efficiency With Respect to Charting Synthesis Optimization Strategies,
Green Processing and Synthesis 2019, doi:10.1515/gps-2018-0131 (open access article)
J. Andraos*, Relationships Between Step and Cumulative PMI and E-factors: Implications on Estimating Material Efficiency With Respect to Charting Synthesis Optimization Strategies,
ChemRxiv 2018, doi: 10.26434/chemrxiv.6686729.v1
Musolino, M.; Andraos, J.; Aricò, F.*, An Easy Scalable Approach to HMF Employing DMC as Reaction Media: Reaction Optimization and Comparative Environmental Assessment,
ChemSelect 2018, 3, 2359-2365.
J. Andraos*, Useful Tools for the Next Quarter Century of Green Chemistry Practice – A Dictionary of Terms and a Dataset of Parameters for High Value Industrial Commodity
Chemicals, ACS Sust. Chem. Eng. 2018, 6, 3206-3214.
J. Andraos*, A New Paradigm for Designing Ring Construction Strategies for Green Organic Synthesis: Implications for the Discovery of Multi-Component Reactions to Build Molecules Containing a Single Ring, Beilstein J. Org. Chem. 2016, 12, 2420-2442. (invited paper)
J. Andraos*, Using Balancing Chemical Equations as a Key Starting Point to Create Green Chemistry Exercises Based on Inorganic Syntheses Examples, J. Chem. Educ. 2016, 93, 1330-1334.
J. Andraos*; Mastronardi, M.L.; Hoch, L.B.; Hent, A. Critical Evaluation of Published Algorithms for Determining Environmental and Hazard Impact Green Metrics of Chemical Reactions and Synthesis Plans, ACS Sust. Chem. Eng., 2016, 4, 1934-1945. (ACS Authors Choice open access article)
J. Andraos*, Critical Evaluation of Published Algorithms for Determining Material Efficiency Green Metrics of Chemical Reactions and Synthesis Plans, ACS Sust. Chem. Eng., 2016, 4, 1917-1933.
J. Andraos*, A Complete Green Metrics Evaluation of Various Routes to Methyl Methacrylate According to Material and Energy Consumptions, and Environmental and Safety Impacts: A Test Case from the Chemical Industry, ACS Sust. Chem. Eng., 2016, 4, 312-323.
J. Andraos*, A. Hent, Useful Material Efficiency Green Metrics Problem Set Exercises for Lecture and Laboratory, J. Chem. Educ. 2015, 92, 1831-1839.
J. Andraos*, A. Hent, Simplified Application of Material Efficiency Green Metrics to Synthesis Plans: Pedagogical Case Studies from Organic Syntheses, J. Chem. Educ. 2015, 92, 1820-1830.
J. Andraos*; E. Ballerini; L. Vaccaro*, “A Comparative Approach to the Most Sustainable Protocol for the b-Azidation of a,b-Unsaturated Ketones and Acids”, Green Chem. 2015, 17, 913-925.
J. Andraos*, On the Probability that Ring-forming Multicomponent Reactions are Intrinsically Green: Setting Thresholds for Intrinsic Greenness Based on Design Strategy and Experimental Reaction Performance, ACS Sust. Chem. Eng. 2013, 1, 496-512.
J. Andraos*, Safety-Hazard Indices: Completion of a Unified Suite of Metrics for the Assessment of “Greenness” for Chemical Reactions and Synthesis Plans, Org. Process Res. Develop. 2013, 17, 175-192.
J. Andraos*, Inclusion of Environmental Impact Parameters in Radial Pentagon Material Efficiency Metrics Analysis: Using Benign Indices as a Step Towards a Complete Assessment of “Greenness” for Chemical Reactions and Synthesis Plans, Org. Process Res. Develop. 2012, 16, 1482-1506.
J. Andraos*; A.P. Dicks*, Green Chemistry Teaching in Higher Education: A Review of Effective Practices, Chem. Educ. Res. Pract., 2012, 13, 69-79.
J. Andraos*, A Green Metrics Assessment of Phosgene and Phosgene-free Syntheses of Industrially Important Commodity Chemicals, Pure Applied Chem.2012, 84, 827-860. (invited paper)
S.M. Mercer; J. Andraos, P.G. Jessop*;, Choosing the Greenest Synthesis: a multivariate metric green chemistry exercise, J. Chem. Educ. 2012, 89, 215-220.
L. Werner; A. Machara; B. Sullivan; I. Carrera; M. Moser; T. Hudlicky*, J. Andraos*, Several Generations of Chemoenzymatic Synthesis of Oseltamivir (Tamiflu): Evolution of Strategy, Quest for a Process-Quality Synthesis, and Evaluation of Efficiency, J. Org. Chem. 2011,76, 10050-10067.
J. Andraos*, A Database Tool for Process Chemists and Chemical Engineers to Gauge the Material and Synthetic Efficiencies of Synthesis Plans to Industrially Important Targets, Pure Applied Chem. 2011, 83, 1361-1378. (invited paper)
J. Andraos*, Global Green Chemistry Metrics Analysis Algorithm and Spreadsheets: Evaluation of the Material Efficiency Performances of Synthesis Plans for Oseltamivir Phosphate (Tamiflu) as a Test Case, Org. Process Res. Develop. 2009, 13, 161 – 185.
J. Andraos* and M. Sayed, On the Use of Green Metrics in the Undergraduate Organic Chemistry Lecture and Practicum to Assess the Material Efficiencies of Organic Reactions, J. Chem. Educ. 2007, 84, 1004 - 1011.
J. Andraos* and J. Izhakova, Perspectives on the Application of Green Chemistry Principles to Total Synthesis Design, Chimica Oggi/The International Journal of Industrial Chemistry and Biotechnology, November/December 2006, 24(6, Supp.), 31 - 36 (invited article).
J. Andraos*, On Using Tree Analysis to Quantify the Material, Input Energy, and Cost Efficiencies of Simple and Complex Synthesis Plans and Networks: toward a blueprint for quantitative total synthesis and green chemistry, Org. Process Research & Development 2006, 10, 212 - 240.
J. Andraos*, Unification of Reaction Metrics for Green Chemistry II: Evaluation of Named Organic Reactions and Application to Reaction Discovery, Org. Process Research & Development. 2005, 9, 404 – 431.
J. Andraos*, Unification of Reaction Metrics for Green Chemistry: Applications to Reaction Analysis, Org. Process Research & Development 2005,9, 149 – 163.
Invited Addresses:
“Life Cycle Assessment (LCA): what you need to know and how to use it”, Future Leaders in Green Chemistry Workshop and Challenge, University of Toronto, CANADA, May 9-10, 2013
“Green Chemistry’s Impact on Research in and Teaching of Organic Synthesis”, University of Toronto, Toronto, CANADA, October 14, 2011
“A Database Tool for Process Chemists and Chemical Engineers to Gauge the Material and Synthetic Efficiencies of Synthesis Plans to Industrially Important Targets”, University of Ontario Institute of Technology, Oshawa, CANADA, October 13, 2010
“Perspectives on Teaching and Research in Green Chemistry”, University of Toronto, Toronto, CANADA, June 5, 2009
"Green Chemistry Metrics: Application to Reaction and Synthesis Optimization", Apotex Pharmachem, Inc., April 22, 2008, Brantford, Ontario, CANADA
15th International Conference on Organic Process Research and Development, "Getting a Grip on Quantifying How Efficient a Synthesis Plan Is For a Given Target Product", San Diego, California, USA, January 8 - 10, 2007
"Getting a Grip on Quantifying How Efficient a Synthesis Plan Is For a Given Target Product", BioVerdant, Inc., San Diego, California, USA, January 11, 2007
“Green Chemistry Principles, Metrics and Industrial Implementation”
Three day training course given by Scientific Update LLP
(co-hosted with Dr. Peter L. Spargo)
Le Centre Sheraton, Montreal, June 19 – 21, 2007
Green Chemistry Metrics for Reaction and Synthesis Optimization, Merck & Co., Rahway, NJ, October 16, 2007
University of Toronto, Sigma-Xi invited address, "The "Algebra" of Organic Synthesis: Green Chemistry and Synthesis Optimization", November 22, 2007
Green Chemistry and Engineering Education Workshop, Chemical Sciences Roundtable, "Green Chemistry: Teaching and Research", National Academies, Washington, D.C., USA, November 7 - 8, 2005
Conferences:
J. Andraos, A. Hent “Comparing the Performance of a Linear and Convergent Synthesis of Bortezomib Using an Integrated Approach to Green Chemistry Metrics at a Gate-to-Gate Level of Analysis”, 251st ACS National Meeting and Exposition, March 13-17, 2016, San Diego, CA, USA
A.P. Dicks, J. Andraos, A. Hent, “Integrating and Applying Green Chemistry Metrics”, International Symposium on Sustainability, March 18-19, 2015,
Mexico City, MEXICOJ. Andraos, “The Importance and Role of Metrics in Green Chemistry”, presented at the 23rd International Conference on Chemical Education (ICCE), July 13-18, 2014, Toronto, Ontario, CANADA
A.P. Dicks, B. Morra, L. Hoch, M. Mastronardi, J. Andraos, presented at the 22nd Symposium on Chemistry and Science Education, June 19-21, 2014, Bremen, GERMANY
J. Andraos, “Combinatorial Connectivity Analysis for the Discovery of New Multi-Component Reactions and Evaluation of their Likelihood to be “Green” Reactions”, presented at the Sustainability Chemistry Summit 2011: From Lab to Market, September 16-18, 2011, Kingston, Ontario, CANADA
J. Andraos, "A Database Tool for Process Chemists and Chemical Engineers to Gauge the Material and Synthetic Efficiencies of Synthesis Plans to Industrially Important Targets", presented at the 3rd International IUPAC Conference on Green Chemistry, August 15 - 18, 2010, Ottawa, Ontario, CANADA
J. Andraos, "Challenges in Launching a University Level Green Chemistry Course for Students and Professional Chemists", presented at the 3rd International IUPAC Conference on Green Chemistry, August 15 - 18, 2010, Ottawa, Ontario, CANADA
J. Andraos, "Challenges in Launching a University Level Green Chemistry Course for Students and Professional Chemists", presented at the 93rd CSC Conference and Exhibition, May 29 - June 2, 2010, Toronto, Ontario, CANADA
J. Andraos, “Linking Synthetic Elegance, Material Efficiency, and Green Chemistry Principles for Synthesis Design and Analysis”, 90th CSC Conference and Exhibition, May 26 – 30, 2007, Winnipeg, Manitoba, CANADA
J. Andraos, "Getting a Grip on Quantifying How Efficient a Synthesis Plan is for a Given Target", presented at the International Symposium on Green Chemical Processes for Pharmaceuticals and Fine Chemicals, October 20 - 22, 2006, McGill University, Montreal, CANADA
J. Andraos and M. Sayed, "On the Use of Green Metrics in the Undergraduate Organic Chemistry Practicum to Assess Material Efficiencies of Organic Reactions", presented at the 89th CSC Conference and Exhibition, May 27 - 31, 2006, Halifax, Nova Scotia, CANADA
J. Andraos, "On Using Tree Analysis to Quantify the Material, Input Energy, and Raw Material Cost Throughput Efficiencies of Simple and Complex Synthesis Plans and Networks", presented at the 89th CSC Conference and Exhibition, May 27 - 31, 2006, Halifax, Nova Scotia, CANADA (poster)
J. Andraos, "Unification of Reaction Metrics: applications to reaction analysis and reaction discovery", presented at the Canada-US Joint Workshop on Innovative Chemistry in Clean Media, May 20 - 21, 2004, McGill University, Montreal, Quebec, CANADA (poster)
J. Andraos, “Assessing Worst Case Scenarios for Organic Reactions using Minimum Atom Economy and Maximum Environmental Impact Factor as Metrics, presented at the 39th IUPAC Congress and 86th CSC Conference and Exhibition, August 10 – 15, 2003, Ottawa, CANADA